Prof. Dr. Emel ARINÇ

Address:
Department of Moleculer Biology and Genetics
Department of Biological Sciences
Middle East Technical University
06531 Ankara
Turkey

Tel       : 90 312 210 5192 / 5161
Fax      : 90 312 210 7976 
E-mail  :earinc@metu.edu.tr

Education:
BSc and MSc in Chemical Engineering, İstanbul University, Turkey (1963)
MSc in Biochemistry, North Carolina State University, Raleigh, N.C., USA (1969)
Ph.D in Biochemistry, North Carolina State University, Raleigh, N.C., USA (1974)

Postdoctoral Fellow:
National Institutes of Environmental Health Sciences/NIH, Molecular Pharmacology Branch (1974-1976)

Research Interests:

General Interests:
Enzymology, Molecular Pharmacology and Toxicology, Ecotoxicology

Special Interests:

Enzyme kinetics
Pharmacogenetics
Toxicogenetics and risk assessment in childhood acute lymphoblastic leukemia
Chemical Carcinogenesis
Drug metabolism, drug-drug; drug-toxicant interactions
The structure, function, and the regulation of the cytochrome P450 dependent drug metabolizing enzymes
Biotechnology and Pollution Monitoring: Use of cytochrome P4501 A protein and associated enzyme induction as biomarkers in the aquatic environment

Publications:

• Main, A.R., Tarkan (Arınç), E., Aull, J.L. and Soucie, W.G.: Purification of horse serum cholinesterase by preparative polyacrylamide gel electrophoresis. The Journal of Biological Chemistry, 247, 566-571, 1972.
   
• Arınç, E. and Philpot, R.M.: Preparation and properties of partially purifed pulmnonary cytochrome P-450 from rabbits. The Journal of Biological Chemistry, 251, 3213-3220, 1976 
   
• Philpot, R.M. and Arınç, E.: Seperation and purification of two forms of hepatic cytochrome P-450 from untreated rabbits. Molecular Pharmacology, 12, 483-493, 1976.

• Arınç, E. and Adalı, O.: Solubilization and partial purification of two forms of cytochrome P-450 from trout liver microsomes. Comparative Biochemistry and Physiology, 76B, 653-662, 1983.

• Arınç E., Rzepecki, L.M. and Strittmatter, P.: Topography of the C terminus of cytochrome b5 tightly bound to dimyristoylphosphatidylcholine vesicles. The Journal of Biological Chemistry, 262, 15563-15567, 1987.

• İşcan, M.Y. and Arınç, E.: Comparison of highly purified sheep liver and lung NADPH-cytochrome P-450 reductases by the analysis of kinetic and catalytic properties. International Journal of Biochemistry, 20,1189-1196,1988.

• Adalı, O. and Arınç, E.: Electrophoretic, spectral, catalytic and immunochemical properties of highly purified cytochrome P-450 from sheep lung. International Journal of Biochemistry, 22, 1433-1444, 1990.

• Arınç, E., Adalı, O., İşcan, M. and Güray, T.: Stimulatory effects of benzene on rabbit liver and kidney microsomal cytochrome P-450 drug metabolizing enzymes. Archives of Toxicology, 65, 186-190, 1991.

• Arınç, E., Adalı, O., Pasha, R.P.K. and Başaran, N.: Different influences of two fractions of lung cytochrome b5 on reconstituted lung benzphetamine N-demethylase system. International Journal of Biochemistry and and Cell Biology, 27, 1095-1105, 1995.

• Başaran, N. and Arınç, E.: Purification and characterization of two forms of microsomal cytochrome b5 from sheep lung. International Journal of Biochemistry and Cell Biology, 30, 719-734, 1998.

• Şen, A. and Arınç, E.: Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunological properties. Comparative Biochemistry and Physiology Part C, 121C, 249-265, 1998.

• Arınç E. and Şen, A., Hepatic Cytochrome P4501A1 and 7-Ethoxyresorufin O-deethylase activities Induction in Mullet and Common Sole as an indicator of Toxic Organic Pollution in Izmir Bay, Turkey. Marine Environmental Research, 48,149-164, 1999.
   
• Arınç, E., Şen, A. and Bozcaarmutlu, A.: Cytochrome P4501A and associated MFO induction in fish as a biomarker for toxic, carcinogenic pollutants in the aquatic environment. Pure and Applied Chemistry, 72 (6) 985-994, 2000.
   
• Arınç, E. and Bozcaarmutlu, A.: Catalyzation of Coca,ne N-demethylation by cytochromes P4502B, P4503A and P4502D in Fish Liver. Journal of Biochemical and Molecular Toxicology, 17, 169-176, 2003.
   
• Bozcaarmutlu, A. and Arınç, E.: Inhibitory effects of divalent metal ions on liver microsomal 7-ethoxyresorufin O-deethylase (EROD) activity of leaping mullet. Marine Environmental Research, 58, 521-524, 2004.
   
• Arınç, E., Arslan, S. and Adalı, O.: Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver. Archives of Toxicology, 79, 427-433, 2005.
   
• Arınç, E., Arslan, S., Bozcaarmutlu, A. and Adalı, O.: Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung. Food and Chemical Toxicology, 45 (1), 105-118, 2007.
   
• Tumer, T.B., Ulusoy, G., Adalı, O., Sahin, G., Gozdasoğlu, S. and Arınç, E.: The low frequency of defective TPMT alleles in Turkish population. A study on pediatric patients with acute lymphoblastic leukemia. American Journal of Hematology, 82 (10), 906-910, 2007.
   
• Ulusoy, G., Adalı, O., Tumer, T.B., Sahin, G., Gozdasoglu, S. and Arınç, E.: significance of Genetic Polymorphisms at Multiple Loci of CYP2E1 in the Risk of Development of Childhood Acute Lymphoblastic Leukemia. Oncology, 72 (1-2), 125-131, 2007.    

Book Chapters:

• Arınç, E.: "Essential features of NADH dependent cytochrome b5 reductase and cytochrome b5 of liver and lung microsomes." pp.140-170. In Arınç, E., Schenkman, J. B., and Hodgson, E. (editors) Molecular Aspects of Monooxygenases and Activation of Toxic Compounds. Plenum Press, New York,1991.

• Arınç, E.:"Extrahepatic Microsomal Forms: Lung microsomal cytochrome P450 isozymes" pp. 373-386. In Schenkman, J. B. and Greim, H. (editors) Handbook of Experimental Pharmacology. Vol.105, Cyrtochrome P450. Springer-Verlag, Heidelberg,1993.

• Arınç, E.: "General aspects of NADPH cytochrome P450 reductase and cytochrome b5." pp. 21-45. In Arınç, E., Schenkman, J. B., and Hodgson, E (editors). Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health, Springer-Verlag, Heidelberg, 1995.

• Arınç, E., and Sen, A., Cytochrome P4501A1 associated enzyme activaties of fish as an indicator of pollution with special reference to Izmir Bay. pp.247-257. In: Arınç, E., Schenkman, J. B., Hodgson, E. (editors), Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes. Plenum Press, New York,1999.

Editorial Board Member:

    Journal of Biochemical and Molecular Toxicology

Awards:

• Higher Education Scholarship Awardee, Turkish Government (1966-1972)
• National Institutes of Health (USA) Fellowship awardee (1974-1976)
• Eczacıbaşı Foundation Science Award in Medicine
• Fulbright Scholar, University of Connecticut Health Center, USA (1984-1985)
• Member of Turkish Academy of Sciences (1996)
• "Science Award" TUBITAK (The Scientific and Technical Research Council of Turkey) (2000)